ADK may refer to:
- ADK (automobile), a Belgian automobile manufactured between 1923 and 1930
- ADK (company) or Alpha Denshi, a video game development company in Japan
- Adenylate kinase, a phosphotransferase enzyme that plays an important role in cellular energy homeostasis
- Adirondack Mountain Club, a nonprofit organization in New York, New Jersey and Massachusetts
- Aggressors of Dark Kombat, an arcade game released by SNK and developed by Alpha Denshi Corp
- Android Open Accessory Development Kit
- Asatsu DK, a Japanese advertising firm
- NZR ADK class
- Adak Airport's IATA Code
- Ardwick railway station's National Rail code
- ADK, a model for tunnel ionization
- Adk, a village in Razavi Khorasan Province, Iran