Adenylate Cyclase - Class II AC

Class II AC

These AC's are toxins secreted by pathogenic bacteria such as Bacillus anthracis and Bordetella pertussis during infection. These bacteria also secrete proteins that enable the AC-II to enter host cells, where the exogenous AC activity undermines normal cellular processes. The genes for Class II AC's are known as cyaA. Several crystal structures are known for AC-II enzymes.