Acute toxicity describes the adverse effects of a substance that result either from a single exposure or from multiple exposures in a short space of time (usually less than 24 hours). To be described as acute toxicity, the adverse effects should occur within 14 days of the administration of the substance.
Acute toxicity is distinguished from chronic toxicity, which describes the adverse health effects from repeated exposures, often at lower levels, to a substance over a longer time period (months or years).
It is widely considered unethical to use humans as test subjects for acute (or chronic) toxicity research. However, some information can be gained from investigating accidental human exposures (e.g., factory accidents). Otherwise, most acute toxicity data comes from animal testing or, more recently, in vitro testing methods and inference from data on similar substances.
Famous quotes containing the word acute:
“The talk shows are stuffed full of sufferers who have regained their health—congressmen who suffered through a serious spell of boozing and skirt-chasing, White House aides who were stricken cruelly with overweening ambition, movie stars and baseball players who came down with acute cases of wanting to trash hotel rooms while under the influence of recreational drugs. Most of them have found God, or at least a publisher.”
—Calvin Trillin (b. 1935)