Symptoms
Symptoms in AIP can be variable. They include abdominal pain which is severe and poorly localized (most common, 95% of patients experience), Urinary symptoms (Dysuria, urinary retention/incontinence or dark urine), peripheral neuropathy (patchy numbness and paresthesias), Proximal motor weakness (usually starting in upper extremities which can progress to include respiratory impairment and death), autonomic nervous system involvement (circulating catecholamine levels are increased, may see tachycardia, hypertension, sweating, restlessness and tremor), neuropsychiatric symptoms (anxiety, agitation, hallucination, hysteria, delirium, depression), Electrolyte abnormalities (Hyponatremia may be due to hypothalamic involvement leading to SIADH that may lead to seizures). Unlike other porphyrias, rash is not typically seen in AIP.
Read more about this topic: Acute Intermittent Porphyria
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