Safety
As with other artificial sweeteners, there is concern over the safety of acesulfame potassium. However, the United States Food and Drug Administration (US FDA) has approved their general use. Critics say acesulfame potassium has not been studied adequately and may be carcinogenic, although these claims have been dismissed by the US FDA and by equivalent authorities in the European Union.
As for potential negative effects, Acesulfame K has been shown to stimulate dose-dependent insulin secretion in rats, though no hypoglycemia was observed, in one animal study from 1987.
One rodent study showed no increased incidence of tumors in response to administration of acesulfame K. In this study, conducted by the National Toxicology Program, 60 rats were given acesulfame K for 40 weeks, making up as much as 3% of their total diet (which would be equivalent to a human consuming 1,343 12-oz cans of artificially sweetened soft drinks every day). There was no sign that these (or lower) levels of acesulfame K increased the rats' risk of cancer or other neoplasms. However, a similar study conducted with p53 haploinsufficient mice showed signs of carcinogenicity in males but not females. Further research in terms of food safety has been recommended.
Research suggests that acesulfame K may affect prenatal development. One study appeared to show that acesulfame K is ingested by mice through their mother's amniotic fluid or breast milk, and that this influences the adult mouse's sweet preference.
Read more about this topic: Acesulfame Potassium
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