Targeting To Multivesicular Bodies
Multivesicular bodies are endosomal compartments that sort ubiquitinated membrane proteins by incorporating them into vesicles. This process involves the sequential action of three multiprotein complexes, ESCRT I to III (ESCRT standing for 'endosomal sorting complexes required for transport'). Vps4p is a AAA-type ATPase involved in this MVB sorting pathway. It had originally been identified as a ”class E” vps (vacuolar protein sorting) mutant and was subsequently shown to catalyse the dissociation of ESCRT complexes. Vps4p is anchored via Vps46p to the endosomal membrane. Vps4p assembly is assisted by the conserved Vta1p protein, which regulates its oligomerzation status and ATPase activity.
Read more about this topic: AAA Proteins
Famous quotes containing the word bodies:
“What is wanted—whether this is admitted or not—is nothing less than a fundamental remolding, indeed weakening and abolition of the individual: one never tires of enumerating and indicting all that is evil and inimical, prodigal, costly, extravagant in the form individual existence has assumed hitherto, one hopes to manage more cheaply, more safely, more equitably, more uniformly if there exist only large bodies and their members.”
—Friedrich Nietzsche (1844–1900)