Targeting To Multivesicular Bodies
Multivesicular bodies are endosomal compartments that sort ubiquitinated membrane proteins by incorporating them into vesicles. This process involves the sequential action of three multiprotein complexes, ESCRT I to III (ESCRT standing for 'endosomal sorting complexes required for transport'). Vps4p is a AAA-type ATPase involved in this MVB sorting pathway. It had originally been identified as a ”class E” vps (vacuolar protein sorting) mutant and was subsequently shown to catalyse the dissociation of ESCRT complexes. Vps4p is anchored via Vps46p to the endosomal membrane. Vps4p assembly is assisted by the conserved Vta1p protein, which regulates its oligomerzation status and ATPase activity.
Read more about this topic: AAA Proteins
Famous quotes containing the word bodies:
“Awareness of the stars and their light pervades the Koran, which reflects the brightness of the heavenly bodies in many verses. The blossoming of mathematics and astronomy was a natural consequence of this awareness. Understanding the cosmos and the movements of the stars means understanding the marvels created by Allah. There would be no persecuted Galileo in Islam, because Islam, unlike Christianity, did not force people to believe in a “fixed” heaven.”
—Fatima Mernissi, Moroccan sociologist. Islam and Democracy, ch. 9, Addison-Wesley Publishing Co. (Trans. 1992)