The lead single off the album was "Como Duele", a Latin pop and ballad song with soft rock and orchestral arrangements, with the main sound being a piano. It was released on 4 November 2008, and became the first single Arjona released under his new label, Warner Music. The song was a critical and commercial hit for the singer, reaching No. 2 on the Billboard Latin Songs chart, and topping the Latin Pop Songs component chart. The music video for "Como Duele" was shot in Mexico City. It was released on 20 October and was directed by the Mexican filmmaker Ricardo Calderón. "Sin Ti... Sin Mi" was chosen as the second single of the album, and was released on January 2009. The song reached No. 4 on both the Latin Songs and Latin Pop Songs chart. Its music video was filmed at the Argentinian Boxing Federation in Buenos Aires. It was directed by Joaquín Cambre. "Ni Tú Ni Yo", featuring Mexican singer Paquita la del Barrio, was released as the third single in some regions, and failed to appear on the US and other national charts. The music video for the song was filmed in black-and-white and features both artists singing around a buffet. Pop ballad "Tocando Fondo" followed as fourth single. The song managed to reach No. 20 on the Latin Songs chart, becoming the third top ten single off 5to Piso on the Latin Pop Songs chart, reaching No. 6. Its music video was filmed in Mexico City. Two other singles, "Suavecito" and "Por Si Regresas" were released in promotion of the album.