3-dehydroquinate Synthase

In enzymology, a 3-dehydroquinate synthase (EC 4.2.3.4) is an enzyme that catalyzes the chemical reaction

3-deoxy-arabino-heptulosonate 7-phosphate 3-dehydroquinate + phosphate

Hence, this enzyme has one substrate, 3-deoxy-arabino-heptulosonate 7-phosphate, and two products, 3-dehydroquinate and phosphate. The protein uses NAD+ to catalyze the reaction. This reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids.

3-dehydroquinate synthase belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis. It employs one cofactor, cobalt.