Deaths
The Partnership for a Drug-Free America reports that 2C-T-7 can be lethal even in small doses, however; they provide no source for their claim and of the three known deaths of 2C-T-7 intoxicated individuals, all involved either excessive insufflated doses or the concomitant ingestion of other stimulants such as ephedrine and MDMA. There have been at least three reported deaths related to 2C-T-7 use as of August, 2007, mainly at insufflated doses of 30 mg or more or combined with stimulants such as MDMA, as well as a number of very uncomfortably intense effects and hospitalizations, these mostly followed insufflation of 2C-T-7. In January 2002, Rolling Stone published an article about 2C-T-7 entitled "The New (legal) Killer Drug", although the legal status of the drug was misrepresented in the article, as 2C-T-7 was already illegal under the United States' analog act. A detailed response on the website Disinformation challenged the accuracy of much of the reporting in that Rolling Stone article.
All of these known deaths of individuals under the influence of 2C-T-7, therefore, occurred in those known either to be intoxicated with potentially deadly stimulants such as ephedrine or MDMA or after the individual insufflated an excessive amount of 2C-T-7- excessive being an amount greater than necessary to induce the full range of the drug's effects, such as the reported 35 mg insufflated dose taken by the individual who died in the Fall of 2000. This reported dose was characterized as "excessive" by the US DEA. Additionally, ephedrine, itself an MAO inhibitor, and MDMA may interact with any monoamine oxidase inhibition by 2C-T-7, which is presently speculative, to increase the cardiotoxicity of MDMA or ephedrine, which together were known to be present in two of the three deaths of 2C-T-7-intoxicated individuals. Ephedrine's cardiovascular effects have previously been shown to be potentiated by some MAO-A inhibitors
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