25-Hydroxyvitamin D3 1-alpha-hydroxylase

25-Hydroxyvitamin D3 1-alpha-hydroxylase

25-Hydroxyvitamin D3 1-alpha-hydroxylase (VD3 1A hydroxylase) also known as cytochrome p450 27B1 (CYP27B1) is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene.

VD3 1A hydroxylase is located in the proximal tubule of the kidney and a variety of other tissues, including skin (keratinocytes), immune cells, and bone (osteoblasts). The enzyme catalyzes the hydroxylation of calcidiol to calcitriol (the bioactive form of Vitamin D):

calcidiol + NADPH + H+ + O2 calcitriol + NADP+ + H2O

  • Calcidiol

  • Calcitriol

calcidiol 1-monooxygenase
Identifiers
EC number 1.14.13.13
CAS number 9081-36-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
Gene Ontology
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PMC articles
PubMed articles
NCBI Protein search

Read more about 25-Hydroxyvitamin D3 1-alpha-hydroxylase:  Interactive Pathway Map