Schedule
| Week | Date | Opponent | Result | Attendance |
|---|---|---|---|---|
| 1 | September 11, 2005 | Houston Texans | W 22–7 |
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| 2 | September 18, 2005 | at Tampa Bay Buccaneers | L 19–3 |
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| 3 | September 25, 2005 | Atlanta Falcons | L 24–16 |
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| 4 | October 2, 2005 | at New Orleans Saints | L 19–7 |
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| 5 | October 9, 2005 | Miami Dolphins | W 20–14 |
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| 6 | October 16, 2005 | New York Jets | W 27–17 |
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| 7 | October 23, 2005 | at Oakland Raiders | L 38–17 |
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| 8 | October 31, 2005 | at New England Patriots | L 21–16 |
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| 9 | Bye | |||
| 10 | November 13, 2005 | Kansas City Chiefs | W 14–3 |
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| 11 | November 20, 2005 | at San Diego Chargers | L 48–10 |
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| 12 | November 27, 2005 | Carolina Panthers | L 13–9 |
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| 13 | December 4, 2005 | at Miami Dolphins | L 24–23 |
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| 14 | December 11, 2005 | New England Patriots | L 35–7 |
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| 15 | December 17, 2005 | Denver Broncos | L 28–17 |
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| 16 | December 24, 2005 | at Cincinnati Bengals | W 37–27 |
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| 17 | January 1, 2006 | at New York Jets | L 30–26 |
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Read more about this topic: 2005 Buffalo Bills Season