2-hydroxyglutarate Dehydrogenase

In enzymology, a 2-hydroxyglutarate dehydrogenase (EC 1.1.99.2) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxyglutarate + acceptor 2-oxoglutarate + reduced acceptor

Thus, the two substrates of this enzyme are (S)-2-hydroxyglutarate and acceptor, whereas its two products are 2-oxoglutarate and reduced acceptor. However, enzymes with specificity to (R)-2-hydroxyglutarate dehydrogenase also exist in both mammals and plants even though they have not been given a unique EC number. This enzyme participates in butanoate metabolism.