1800s in The United States - 16th Century

16th Century

Year Date Event
1513 Spanish explorer Vasco Núñez de Balboa crossed the Isthmus of Panama.
Spanish conquest of Yucatán: The Spaniard Juan Ponce de León defeated the state of Tlaxcala.
1520 Spanish conquest of Yucatán: Spanish conquest of the Maya civilization began.
1521 Spanish conquest of the Aztec Empire: Spanish conquistador Hernán Cortés destroyed the Aztec Empire.
1524 Giovanni da Verrazzano explored the Atlantic coast of North America under French employ.
1542 Spanish explorer Hernando de Soto discovered the Mississippi River, strengthening Spanish claims to the interior of North America.
1565 Spanish Admiral Pedro Menéndez de Avilés founded St. Augustine.
1570 The Iroquois Confederacy was founded.
1587 English explorer Sir Walter Raleigh founded Roanoke Colony.
1590 The Roanoke Colony was found deserted.

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