Zo may refer to:
- Zo (people), an indigenous tribe in Burma
- Zo'é language, a language originating in Brazil
People:
- Alonzo Mourning (born 1970) nicknamed Zo, a retired basketball player
- Lorenzo Charles (born 1963) nicknamed Zo, a basketball player born in New York
- Mat Zo, a trance artist from the UK
- Zo d'Axa, (1864–1930), an adventurer, anti-militarist, satirist, journalist, and founder of two French magazines, L'EnDehors and La Feuille
In art and culture:
- Jij bent zo, a single by Dutch singer Jeroen van der Boom, released in 2007
- Kamen Rider ZO, a 1993 Japanese tokusatsu movie
- The Zorcerer of Zo, a fairy tale-themed role-playing game created by Chad Underkoffler
- Tora Zo, the Cypriot entry in the Eurovision Song Contest 1986, performed in Greek by Elpida
- Zo'or, a character in the science fiction television series Earth: Final Conflict, played by Anita La Selva
- Zus & Zo, a 2001 Dutch film directed by Paula van der Oest
Other:
- Renault Zo, an open top car from Renault which was introduced in 1998 at the Geneva motor show
- Dzo, a male hybrid of a yak and a domesticated cow
- Zo Artzeinu, a political protest movement in Israel
- Zone occupée, the partition of France occupied by German troops during the initial years of World War II
- ZO sex-determination system in biology