ZF may refer to:
- Zelda Fitzgerald, the wife of F. Scott Fitzgerald
- Zermelo–Fraenkel set theory, a system of axioms in mathematical set theory
- Zend Framework, a popular web application framework implemented with PHP 5
- ZF Friedrichshafen, a leading German supplier of automobile transmissions
- Zinc finger, a protein domain that interacts with zinc ion to bind to DNA
- Zionist Federation of Great Britain and Ireland, an organization established to campaign for a permanent homeland for the Jewish people
- Z Fighters, the protagonists of the Dragon Ball saga