Wykeham could be
- Places
- Wykeham, Lincolnshire, a series of Deserted Medieval Villages
- East Wykeham, Ludford, Lincolnshire, in the civil parish of Ludford
- West Wykeham, Ludford, Lincolnshire, in the civil parish of Ludford
- Wykeham, Nettleton, Lincolnshire, near Nettleton Top, Nettleton
- Wykeham, Weston, Lincolnshire, in the civil parish of Weston
- Wykeham, Scarborough, North Yorkshire, England
- Wykeham, Ryedale, North Yorkshire, England
- People
- William of Wykeham
- Peter Wykeham, British air marshal
- Other
- The Wykeham Collegiate, South Africa