Witte is a surname. Notable people with the surname include:
- Alfred Witte (1878–1941), German astrologer
- Dave Witte, an American metal and hardcore punk drummer
- Edwin E. Witte (1887–1960), "father of social security"
- Emanuel de Witte (1617–1691), Dutch perspective painter
- Erich Witte (1911–2008), German tenor
- Gaspar de Witte (1624–1681), a Flemish painter of the Baroque period
- Jacob Eduard de Witte, Dutch architect, author of the fortification project of Tallinn
- Jan de Witte (1709–1785), Dutch-Polish military engineer and architect
- Jean Carlo Witte (born 1977), Brazilian football (soccer) player
- Joe Witte (born 1943), American weatherman
- Les Witte, American college basketball player
- Luke Witte (born 1950), American basketball player
- Otto Witte (1872–1958), German circus acrobat
- Sergei Witte (1849–1915), Russian policy-maker
- Terry L. Witte (born 1952), American attorney and politician
- William Henry Witte (1817–1876), American politician
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