Wertheim may refer to:
- Wertheim vacuum cleaner, a brand of vacuum cleaner
- Wertheim am Main, Baden-Württemberg, Germany
- Wertheim (department store), a chain of German department stores. The Wertheim group was founded by Georg Wertheim
- Wertheim's hysterectomy, with excision of the entire uterus, the connective tissue and lymph nodes close to it, Fallopian tubes, ovaries, and the upper part of the vagina.
- Wertheim Piano, an Australian brand of piano
- Wertheim National Wildlife Refuge, a protected wetlands on Long Island, New York
- Wertheim & Co., an investment firm
Wertheim is a German Christian family and Ashkenazi Jewish surname originated from Wertheim or Wertheim County. It may refer to:
- Adelaide of Löwenstein-Wertheim-Rosenberg (1831-1909), wife of King Miguel of Portugal
- Alois-Konstantin, 9th Prince of Löwenstein-Wertheim-Rosenberg (born 1941), German businessman and head of the high-noble House of Löwenstein-Wertheim-Rosenberg
- Aloys, 7th Prince of Löwenstein-Wertheim-Rosenberg (1871-1952), German politician and the President of the Central Committee of German Catholics
- Anastasia, Princess of Löwenstein-Wertheim-Rosenberg (born 1944), consort of Alois-Konstantin, 9th Prince of Löwenstein-Wertheim-Rosenberg
- Charles, 6th Prince of Löwenstein-Wertheim-Rosenberg (1834-1921), German nobleman, the Prince of Löwenstein-Wertheim-Rosenberg
- Charles Thomas, Prince of Löwenstein-Wertheim-Rosenberg (1783-1849), Austrian officer during the Napoleonic Wars
- Constantine, Hereditary Prince of Löwenstein-Wertheim-Rosenberg (1802-1838), eldest son and heir of Charles Thomas, Prince of Löwenstein-Wertheim-Rosenberg
- Countess Eleonore of Löwenstein-Wertheim (1686–1753), Princess of the Löwenstein-Wertheim-Rochefort
- Dick Wertheim (died 1983), American tennis linesman
- Eric Wertheim (born 1973), American naval expert, columnist and author
- Ernst Wertheim (1864-1920), Austrian gynecologist
- Georg Wertheim (1857–1939), German merchant
- Géza Wertheim (1910-after 1957), Luxembourgian tennis player and bobsledder
- Guillame Wertheim, see Wiedemann effect
- Herbert Wertheim, American inventor, scientist, educator and clinician
- Hubertus Prinz zu Löwenstein-Wertheim-Freudenberg (1906–1984), German writer, journalist, politician
- John Wertheim (born 1968), American lawyer and politician
- Juliusz Wertheim (1880-1928), Polish pianist, conductor and composer
- L. Jon Wertheim, American sports journalist and author
- Lucy Wertheim (1883–1971), English art dealer
- Margaret Wertheim (born 1958), Australian international science writer and commentator
- Maurice Wertheim (1886–1950), American investment banker, chess player, and philanthropist
- Micha Wertheim (born 1972), Dutch stand-up comedian and satirist
- Nicodemus, Hereditary Prince of Löwenstein-Wertheim-Rosenberg (born 2001), heir to the House of Löwenstein-Wertheim-Rosenberg
- Pierre Wertheim (1888-1971), French World War I flying ace
- Prince Ludwig of Löwenstein-Wertheim-Freudenberg (1864-1899), London socialite
- Princess Anne of Löwenstein-Wertheim-Freudenberg (1864-1927), English socialite and aviation patron and enthusiast
- Princess Maria Theresa of Löwenstein-Wertheim-Rosenberg (1870-1935), Princess of Löwenstein-Wertheim-Rosenberg
- Rosy Wertheim (1888-1949), Dutch pianist, music educator and composer
- Theodor Wertheim (1820-1864), Austrian chemist