VBR may refer to:
- Variable bitrate, in telecommunications and computing, when the bitrate used in sound or video encoding is not held constant
- Volume Boot Record, in computer disks, a type of boot sector that contains code for bootstrapping programs
- Vector Base Register
- The Reverse Breakdown Voltage with a diode in electronics.
- Vinnell-Brown & Root, a private contractor that provides base maintenance support for the U.S. military in Turkey
- Vouch by Reference, a standard way for email certification providers to vouch for outbound email sent by others
- Very Best Regards, an abbreviation often used in text messages or e-mail
- Ventricle to brain ratio, in medicine, the total volume of the brain ventricles divided by the total brain volume on medical imagery