VAPA

VAPA

Identifiers Symbols VAPA; VAP-33; VAP-A; VAP33; hVAP-33 External IDs OMIM: 605703 MGI: 1353561 HomoloGene: 37824 GeneCards: VAPA Gene

Gene Ontology
Molecular function	• signal transducer activity • structural molecule activity • protein binding • protein heterodimerization activity
Cellular component	• endoplasmic reticulum • endoplasmic reticulum membrane • microtubule • plasma membrane • tight junction • integral to membrane • vesicle • perinuclear region of cytoplasm
Biological process	• sphingolipid metabolic process • cellular membrane fusion • signal transduction • cell death • sphingolipid biosynthetic process • neuron projection development • positive regulation of I-kappaB kinase/NF-kappaB cascade • small molecule metabolic process • protein localization to endoplasmic reticulum
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9218 30960 Ensembl ENSG00000101558 ENSMUSG00000024091 UniProt Q9P0L0 Q9WV55 RefSeq (mRNA) NM_003574 NM_013933 RefSeq (protein) NP_003565 NP_038961 Location (UCSC) Chr 18:
9.91 – 9.96 Mb Chr 17:
65.58 – 65.61 Mb PubMed search

Vesicle-associated membrane protein-associated protein A is a protein that in humans is encoded by the VAPA gene.

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.