Major Intersections
| County | Location | Mile | Destinations | Notes | ||
|---|---|---|---|---|---|---|
| Savannah River | 0.0 | Georgia - South Carolina state line Concurrent with US 25 / US 78 / US 278 / SC 121 |
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| Aiken | North Augusta | 0.7 | US 25 / SC 121 / SC 230 (E Martintown Road) | North end of US 25 / SC 121 concurrency, eastern terminus of SC 230 | ||
| 1.4 | I-520 (Palmetto Parkway) | Exit 17 on Interstate 520 | ||||
| Clearwater | 2.2 | US 278 / SC 125 (Atomic Road) / SC 421 north | North end of US 278 concurrency; Southern terminus of SC 421 | |||
| 4.0 | SC 126 (Belvedere-Clearwater Road) | |||||
| Graniteville | 10.3 | SC 191 (Main Street) | ||||
| Aiken | 12.3 | SC 19 / SC 118 (Robert M Bell Parkway/Hitchcock Parkway) | ||||
| 12.4 | SC 421 (Augusta Road) | Northern terminus of SC 421 | ||||
| 15.5 | SC 19 (Laurens Street NW) | South end of SC 19 concurrency | ||||
| 15.7 | SC 19 (Chesterfield Street S) | North end of SC 19 concurrency | ||||
| 15.8 | US 78 (Augusta Aiken Road) | North end US 78 concurrency | ||||
| 17.3 | SC 118 (Rutland Drive/Rudy Mason Parkway) | |||||
| 23.8 | I-20 | Exit 22 on Interstate 20 | ||||
| Ridge Spring | 33.6 | SC 392 (Engineer Road) | Eastern terminus of SC 392 | |||
| Monetta | 37.3 | SC 39 (Main Street/Old Ninety-Six Indian Trail) | ||||
| Saluda | No major junctions | |||||
| Lexington | Batesburg-Leesville | 43.1 | US 178 / SC 391 (Pine Street) | |||
| 45.2 | SC 245 (Lee Street) | |||||
| 46.5 | SC 23 (Leesville Avenue) | Northern terminus of SC 23 | ||||
| Lexington | 61.1 | US 378 | South end of US 378 concurrency | |||
| 61.7 | US 378 (Columbia Avenue) | North end of US 378 concurrency | ||||
| 62.4 | SC 6 (Lake Drive) | |||||
| 64.8 | I-20 | Exit 58 on Interstate 20 | ||||
| West Columbia | 70.0 | I-26 | Exit 111A-B on Interstate 26 | |||
| 70.8 | SC 12 (Jarvis Klapman Boulevard) | Western terminus of SC 12 | ||||
| 73.3 | SC 2 (State Street) | Eastern terminus of SC 2 | ||||
| 73.3 | US 378 (Sunset Boulevard) | South end of US 378 concurrency | ||||
| Richland | Columbia | 73.9 | US 21 / US 176 / US 321 | |||
| 74.5 | SC 48 (Assembly Street) | Western terminus of SC 48 | ||||
| 74.9 | US 76 (Bull Street) | South end of US 76 concurrency | ||||
| 75.8 | US 76 / US 378 (Millwood Avenue) | North end of US 76 / US 378 concurrency | ||||
| 76.2 | SC 12 (Taylor Street/Forest Drive) | |||||
| 78.0 | SC 16 (Beltline Boulevard) | |||||
| Dentsville | 82.2 | I-20 | Exit 74 on Interstate 20 | |||
| 83.0 | I-77 (Veterans Memorial Freeway) | Exit 17 on Interstate 77 | ||||
| Pontiac | 88.2 | Clemson Road | ||||
| Kershaw | Lugoff | 101.1 | US 601 (Jamie Lane) | South end of US 601 concurrency | ||
| 101.7 | SC 34 (Ridgeway Road/Ward Road) | South end of SC 34 concurrency | ||||
| Camden | 104.2 | US 521 / US 601 (Springdale Drive) | North end of US 601 concurrency | |||
| 106.4 | US 521 / US 601 (Broad Street) | |||||
| 107.8 | SC 34 (Bishopville Highway) | North end of SC 34 concurrency | ||||
| Bethure | 126.7 | SC 341 (Main Street) | ||||
| Chesterfield | McBee | 133.5 | SC 151 (Pine Avenue) | |||
| 135.4 | SC 145 | Southern terminus of SC 145 | ||||
| Patrick | 148.3 | SC 102 (Poison Street/Turnage Street) | ||||
| Cheraw | 158.1 | US 52 | South end of US 52 concurrency | |||
| 160.5 | SC 9 (Market Street) | South end of SC 9 concurrency | ||||
| 161.7 | US 52 (2nd Street) | North end of US 52 concurrency | ||||
| Marlboro | Wallace | 163.6 | SC 9 | North end of SC 9 concurrency | ||
| 170.1 | South Carolina - North Carolina state line | |||||
Read more about this topic: U.S. Route 1 In South Carolina
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