UBE2G2

Identifiers Symbols UBE2G2; UBC7 External IDs OMIM: 603124 MGI: 1343188 HomoloGene: 6599 GeneCards: UBE2G2 Gene EC number 6.3.2.19

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • protein binding • ATP binding
Cellular component	• endoplasmic reticulum • cytosol
Biological process	• ubiquitin-dependent protein catabolic process • protein N-linked glycosylation via asparagine • ER-associated protein catabolic process • protein K48-linked ubiquitination
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7327 22213 Ensembl ENSG00000184787 ENSMUSG00000009293 UniProt P60604 P60605 RefSeq (mRNA) NM_001202489 NM_019803 RefSeq (protein) NP_001189418 NP_062777 Location (UCSC) Chr 21:
46.19 – 46.22 Mb Chr 10:
77.62 – 77.65 Mb PubMed search

Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Ube2g2 is known to interact with a variety of other proteins, including but not limited to ubiquitin, the E3 gp78, and the Hrd1 RING.