Transmutation may refer to:
- Biological transmutation, the claim that nuclear transmutation occurs within living organisms
- Dimensional transmutation, a physical mechanism that transforms a pure number into a parameter with a dimension
- Nuclear transmutation, the conversion of one chemical element or isotope into another through nuclear reaction
- Transmutation of species, the alteration of one species into another
- Transubstantiation, dogmatic theory of the Eucharist in Roman Catholic theology
- Transmutate, a fictional character in the Transformers universe
- Transmutation circle, a circle used to perform alchemy in Fullmetal Alchemist
- Transmutations, a film screenplayed by horror-writer Clive Barker
- Transmutation (Mutatis Mutandis), an album by the supergroup Praxis
- Transmutation (album), an album by the Brazilian death metal band Ophiolatry
- Sexual transmutation, Sexual sublimation, an attempt to transform sexual energy into creativity and thereby facilitate spiritual awakening
- Transmuting metals, Alchemy, turning inexpensive metals, such as lead, into gold