Tonawanda may refer to:
- Glacial Lake Tonawanda
- North Tonawanda, New York, a city in Niagara County, north across Tonawanda Creek from the City and Town
- Tonawanda (CDP), New York, consisting of the Town of Tonawanda less the Village of Kenmore
- Tonawanda (city), New York, officially City of Tonawanda, established 1904, bordered on three sides by the Town of Tonawanda
- Tonawanda (town), New York, officially Town of Tonawanda, established 1836, in Erie County north of Buffalo, New York
- Tonawanda (25th Separate Company) Armory, listed on the National Register of Historic Places
- Tonawanda Band of Seneca Indians
- Tonawanda Creek, a tributary of the Niagara River and part of the Erie Canal
- Tonawanda Kardex, a defunct NFL team based in North Tonawanda
- Tonawanda Reservation, on Tonawanda Creek in Erie, Genesee, and Niagara counties