Guest Appearances
- Norma Crane made two appearances playing different roles in the episodes: A Threatened Species and Crisis.
- Linda Dangcil also made two appearances playing different roles in the episodes: A Matter of Priorities and To Save a Life.
- Pat Hingle as Dr. Ben Gold and Walsh in the episodes: Glass Cage and To Save a Life
- Darby Hinton as Hal Parker in "This Will Really Kill You"
- Jane Wyman as Dr. Amanda Fallon in the episodes: And Other Things I May Not See and Discovery at Fourteen
- Clu Gulager as Dan Corwin/ Matt Smith in the episodes: End Theme and A Threatened Species
- Tisha Sterling as Casey Woods/Joan in the episodes: This Will Really Kill You and What's the Price of a Pair of Eyes?
- Sheila Larken as Liz in the episodes: A Substitute Womb and This Day's Child
- Joanne Linville as Anne Sorenson/Joan Stedman in the episodes: Time Bomb in the Chest and In Dreams They Run
- Ron Howard as a fourteen-year-old, who discovers that his father is homosexual in "Discovery at Fourteen"
Read more about this topic: The Bold Ones: The New Doctors
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