TCO can mean:
- Top Coder Open
- Total cost of ownership — a method of cost analysis
- Swedish Confederation of Professional Employees (Tjänstemännens Centralorganisation) — a Swedish confederation of trade unions
- TCO Certification, a certification for computer displays and other office equipment.
- Tail-call optimization, a computer programming concept
- Transparent conducting oxide, a type of transparent conducting film in electronics.
- Thermal cutoff, a type of electronic protection component
- The Cinematic Orchestra, a British-based jazz and electronic music outfit
- Temporary Certificate of Occupancy
- Native Community Lands (Tierras Comunitarias de Origen), Bolivian collectively indigenous territories
- Temporarily-captured orbiter, an object that makes at least one revolution around the Earth in a co-rotating coordinate system.
- Transnational Criminal Organizations