Adverse Effects
Sulbutiamine has few reported adverse effects at therapeutic dosages. According to the manufacturer of Arcalion, a mild skin allergy may occur, and mild agitation has also been observed in elderly patients. In 2006 a patient with bipolar disorder was prescribed sulbutiamine because he was complaining of a lack of energy. The patient found the medication helpful, and began taking 2 g per day, far more than prescribed. Subsequently he stopped taking the other prescription medications and insisted that sulbutiamine was the only medication that helped him. The authors of the report conclude that sulbutiamine has the potential to interfere with the therapeutic outcome of bipolar disorder, although this was an indirect effect since the patient's suspension of his other medications ultimately caused the issue with his treatment.
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