Safety Studies
Results from over 100 animal and clinical studies in the FDA approval process unanimously indicated a lack of risk associated with sucralose intake. However, some adverse effects were seen at doses that significantly exceeded the estimated daily intake (EDI), which is 1.1 mg/kg/day. When the EDI is compared to the intake at which adverse effects are seen, known as the highest no adverse effects limit (HNEL), at 1500 mg/kg/day, there is a large margin of safety. The bulk of sucralose ingested is not absorbed by the gastrointestinal (GI) tract and is directly excreted in the feces, while 11-27% of it is absorbed. The amount absorbed from the GI tract is largely removed from the blood stream by the kidneys and eliminated in the urine, with 20-30% of the absorbed sucralose being metabolized.
Read more about this topic: Sucralose, Health, Safety, and Regulation
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