Expression and Tissue Distribution
STIM2 mRNA is expressed by most human tissues. The STIM2 protein is expressed by many human cell lines together with STIM1, indicating that STIM isoforms are co-expressed in the same cell, at least in the established cell lines. STIM2 protein is widely expressed in tissues, usually present at lower levels than STIM1 except in brain or liver, were STIM2 seems to be the dominant isoform. Stim2 transcription is also dynamically regulated, for instance being upregulated upon differentiation of naive T cells into Th1 or Th2 lymphocytes.
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