Sprouse is a surname. Notable people with the surname include:
- Bill Sprouse Jr. (born 1975), American Christian evangelist and singer
- Chris Sprouse (born 1966), American comic book artist
- Dylan and Cole Sprouse (born 1992), American actors, identical twins
- Stephen Sprouse (1953–2004), American fashion designer
- Vic Sprouse (contemporary), American politician from West Virginia
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