Spitzer may refer to:
- Andre Spitzer, Israel's 1972 Summer Olympics fencing coach and victim of the Munich massacre
- Bernard Spitzer, father of Eliot Spitzer
- Eliot Spitzer, 54th Governor of the State of New York
- Frank Spitzer Austrian-born American mathematician
- Leo Spitzer, Austrian linguist
- Lyman Spitzer, an American theoretical physicist
- Robert R. Spitzer, industrialist
- Robert Spitzer (political scientist), American political scientist
- Robert Spitzer (psychiatrist), American psychiatrist
- Toba Spitzer, president of the Reconstructionist Rabbinical Association
- Todd Spitzer, member of the California State Assembly