Spiteri is a common Maltese surname. It may refer to:-
- Donat Spiteri, Maltese religious leader and author
- Mary Spiteri, Maltese cabaret artiste
- Oliver Spiteri, Maltese soccer manager and former player
- Renzo Spiteri, Maltese musician
- Sharleen Spiteri, Scottish singer (of Maltese ancestry) and frontwoman of the band Texas
- Glenn Spiteri, A.R.P.S., American born, Scottish based photographer. DOB 29/08/1951
- Salvino Spiteri, founder of Malta Workers' Union (UĦM)
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