SPF may refer to:
- In human rights
- Sydney Peace Foundation
- In science
- Specific Pathogen Free, a term for laboratory animals known to be without pathogens
- Supernatant Protein Factor, cytosolic protein known also as SEC14L2, Tap-1 (Tocopherol Associated Protein 1)
- Superplastic forming, a metalworking process for forming sheet metal
- Sun protection factor, a laboratory measure of the effectiveness of sunscreen
- In mathematics
- Formal spectrum of a ring, a construction in algebraic geometry
- In computing and telecommunications
- Sender Policy Framework, an e-mail anti-forgery system
- Shortest Path First, another name for Dijkstra's algorithm
- Single point of failure in systems
- STEP Physical File, ISO 10303-21 data encoding standard
- Sunbelt Personal Firewall, a desktop personal firewall
- Structured Programming Facility, an early version of the ISPF application framework. A more recent version was named System Productivity Facility,
- System Productivity Facility, an early version of the ISPF application framework, replacing the Structured Programming Facility field developed program (FDP) and program product.
- In government and politics
- Security Policy Framework, an overarching security policy set by UK government
- Special Police Force
- Singapore Police Force
- South Pacific Forum
- Space Power Facility, an experimental vacuum chamber for NASA
- Special Purpose Forces, highly trained and advanced soldiers
- Socialist Party of Florida, an affiliate of the Socialist Party USA
- Servicio Penitenciario Federal, the Argentine federal administration in charge of prisons
- In construction
- Spray polyurethane foam
- Spruce-pine-fir, mixed softwood timber
- Other uses
- Summer Play Festival
- Black Hills Airport, South Dakota, IATA airport code