Spedding is a surname, and may refer to:
- Alison Spedding (born 1962), British anthropologist and fantasy author
- Charlie Spedding (born 1952), long-distance runner
- Chris Spedding (born 1944), English rock and roll and jazz guitarist
- Cory Spedding (born 1991), British singer
- David Spedding (1943-2001), Head of the British Secret Intelligence Service
- Frank Spedding (1902-1984), American chemist
- James Spedding (1808-1881), English author
- Jim Spedding (born 1912), former professional footballer
- Sam Spedding (21st century), English actor and comedian
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