Small Nucleolar RNA SNORD75 (also known as U75) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
U75 (SNORD75) belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. The mouse snoRNA Z19 is orthologous to human U75. U75 is predicted to guide the 2'-O-ribose methylation of 28S ribosomal RNA (rRNA) residue C4032. In humans U75 shares the same non-protein coding host gene (gas5) with 9 other snoRNAs (U44, U47, U74, U76, U77, U78, U79, U80 and U81).
Famous quotes containing the word small:
“Beauty depends on size as well as symmetry. No very small animal can be beautiful, for looking at it takes so small a portion of time that the impression of it will be confused. Nor can any very large one, for a whole view of it cannot be had at once, and so there will be no unity and completeness.”
—Aristotle (384 B.C.–322 B.C.)