SIRT6

SIRT6

Identifiers Symbols SIRT6; SIR2L6 External IDs OMIM: 606211 MGI: 1354161 HomoloGene: 6924 GeneCards: SIRT6 Gene EC number 2.4.2.31

Gene Ontology
Molecular function	• NAD+ ADP-ribosyltransferase activity • NAD(P)+-protein-arginine ADP-ribosyltransferase activity • protein binding • zinc ion binding • NAD-dependent histone deacetylase activity • NAD-dependent histone deacetylase activity (H3-K9 specific) • NAD+ binding
Cellular component	• nucleus • nucleoplasm • nuclear telomeric heterochromatin • nucleolus
Biological process	• protein ADP-ribosylation • regulation of double-strand break repair via homologous recombination
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 51548 50721 Ensembl ENSG00000077463 ENSMUSG00000034748 UniProt Q8N6T7 P59941 RefSeq (mRNA) NM_001193285 NM_001163430 RefSeq (protein) NP_001180214 NP_001156902 Location (UCSC) Chr 19:
4.17 – 4.18 Mb Chr 10:
81.62 – 81.63 Mb PubMed search

Sirtuin-6 (SIRT6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. SIRT6 functions in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation.