Sequencing Performance
Pacific Biosciences commercialized SMRT sequencing in 2011, after releasing a beta version of its instrument in late 2010. In April 2013, the company released a new version of the sequencer called the "PacBio RS II" that offered higher throughput and longer sequence reads.
The prototype of the SMRT chip contained ~3000 ZMW holes that allowed parallelized DNA sequencing. In 2012, the SMRT Cells were each patterned with 150,000 ZMW holes that are read in two sets of 75,000.
A new chemistry kit released in 2012 increased the sequencer's read length; an early customer of the chemistry cited mean read lengths of 2.5 to 2.9 kilobases.
Read more about this topic: Single Molecule Real Time Sequencing
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“What avails it that you are a Christian, if you are not purer than the heathen, if you deny yourself no more, if you are not more religious? I know of many systems of religion esteemed heathenish whose precepts fill the reader with shame, and provoke him to new endeavors, though it be to the performance of rites merely.”
—Henry David Thoreau (1817–1862)