Simonton may refer to:
- Simonton, Texas, city in Fort Bend County, Texas
- Simonton Lake, Indiana, census-designated place in Elkhart County, Indiana
- Ann Simonton, writer, lecturer and feminist media activist
- Ashbel Green Simonton, (1833-1867), American Presbyterian minister and missionary
- Charles Bryson Simonton (1838-1911), member of the United States House of Representatives
- Charles Henry Simonton (1829–1904), United States federal judge
- John Simonton (1943–2005), circuit designer
- Ken Simonton (1979-), American football running back
- Richard Simonton (1915-1979), also known as Doug Malloy, Hollywood businessman and entrepreneur
- William Simonton (1788-1846), Whig member of the U.S. House of Representatives from Pennsylvania