Setzer is surname of:
- Family name
- Arlene Setzer, Republican member of the Ohio House of Representatives
- Brian Setzer (born 1959), an American guitarist and songwriter
- The Brian Setzer Orchestra, a swing band
- The Brian Setzer Orchestra (album)
- Claudia J. Setzer, author
- Dennis Setzer, an American race car driver
- Henry W. Setzer (1916, Moline, Illinois - 1992, Gainesville, Florida), an American zoologist
- Setzer's Hairy-footed Gerbil (Gerbillurus setzeri), a species of rodent in the Muridae family
- Setzer's mouse-tailed dormouse (Myomimus setzeri), a species of rodent in the Gliridae family
- Setzer's Pygmy Mouse (Mus setzeri), a species of rodent in the Muridae family
- Johanna Setzer (born 1979), Austrian TV presenter
- Jürgen Setzer
- Matthew Setzer, an US musician, composer, and music technologist
- Michael Setzer
- Mitchell Smith Setzer, a Republican member of the North Carolina General Assembly
- Valdemar W. Setzer
- Species
- Setzer's Hairy-footed Gerbil (Gerbillurus setzeri), a species of rodent in the Muridae family
- Setzer's mouse-tailed dormouse (Myomimus setzeri), a species of rodent in the Gliridae family
- Setzer's Pygmy Mouse (Mus setzeri), a species of rodent in the Muridae family
- Fictional figures
- Setzer Gabbiani, a fictional character in the Square video game Final Fantasy VI