Principles
Radiation therapy is used to kill cancer cells; however, normal cells are also damaged in the process. Currently, therapeutic doses of radiation can be targeted to tumors with great accuracy using linear accelerators (see radiation oncology); however, the normal liver tissue is very sensitive to external beam radiotherapy. Fortunately, malignancies (including primary and metastatic liver cancers) are often hypervascular; tumor blood supplies are often increased compared to those of normal tissue. Furthermore, the liver has a dual blood supply, receiving blood from both the hepatic artery and the portal vein. Hepatic malignancies derive most of their blood supply from the hepatic artery; whereas the normal liver derives most of its blood supply from the portal vein. Therefore, delivery of radioembolic particles through the branch of the hepatic artery supplying a tumor will preferentially lead to deposition of the particles in the tumor, while sparing normal liver from harmful side effects.
Read more about this topic: Selective Internal Radiation Therapy
Famous quotes containing the word principles:
“Unless democracy is to commit suicide by consenting to its own destruction, it will have to find some formidable answer to those who come to it saying: “I demand from you in the name of your principles the rights which I shall deny to you later in the name of my principles.””
—Walter Lippmann (1889–1974)
“The principles which men give to themselves end by overwhelming their noblest intentions.”
—Albert Camus (1913–1960)
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—Robert Benchley (1889–1945)