Potential Applications
In chronic inflammatory diseases of the skin like atopic dermatitis, the side-effects of corticoids are problematic because of the necessary long-term treatment. Therefore, SEGRAs are being investigated as an alternative topical treatment. Systemic long-term treatment of inflammations with corticoids is particularly liable to cause metabolic side-effects, which makes the development of oral SEGRAs an interesting goal. Inflammatory diseases of the eye are also a potential application because corticoids can promote glaucoma, cataract, and eye infections. It remains to be seen whether selective receptor agonists cause significantly less side-effects than classical corticoids in clinical application.
The atrophic effects of glucocorticoids are not always a disadvantage. The treatment of hyperproliferative diseases like psoriasis makes use of this property. SEGRAs would likely be less effective in such conditions.
Read more about this topic: Selective Glucocorticoid Receptor Agonist
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“Silence is as full of potential wisdom and wit as the unhewn marble of great sculpture. The silent bear no witness against themselves.”
—Aldous Huxley (1894–1963)