Potential Applications
In chronic inflammatory diseases of the skin like atopic dermatitis, the side-effects of corticoids are problematic because of the necessary long-term treatment. Therefore, SEGRAs are being investigated as an alternative topical treatment. Systemic long-term treatment of inflammations with corticoids is particularly liable to cause metabolic side-effects, which makes the development of oral SEGRAs an interesting goal. Inflammatory diseases of the eye are also a potential application because corticoids can promote glaucoma, cataract, and eye infections. It remains to be seen whether selective receptor agonists cause significantly less side-effects than classical corticoids in clinical application.
The atrophic effects of glucocorticoids are not always a disadvantage. The treatment of hyperproliferative diseases like psoriasis makes use of this property. SEGRAs would likely be less effective in such conditions.
Read more about this topic: Selective Glucocorticoid Receptor Agonist
Famous quotes containing the word potential:
“Most days I feel like an acrobat high above a crowd out of which my own parents, my in-laws, potential employers, phantoms of “other women who do it” and a thousand faceless eyes stare up.”
—Anonymous Mother. Ourselves and Our Children, by Boston Women’s Health Book Collective, ch. 2 (1978)