Potential Applications
In chronic inflammatory diseases of the skin like atopic dermatitis, the side-effects of corticoids are problematic because of the necessary long-term treatment. Therefore, SEGRAs are being investigated as an alternative topical treatment. Systemic long-term treatment of inflammations with corticoids is particularly liable to cause metabolic side-effects, which makes the development of oral SEGRAs an interesting goal. Inflammatory diseases of the eye are also a potential application because corticoids can promote glaucoma, cataract, and eye infections. It remains to be seen whether selective receptor agonists cause significantly less side-effects than classical corticoids in clinical application.
The atrophic effects of glucocorticoids are not always a disadvantage. The treatment of hyperproliferative diseases like psoriasis makes use of this property. SEGRAs would likely be less effective in such conditions.
Read more about this topic: Selective Glucocorticoid Receptor Agonist
Famous quotes containing the word potential:
“If the Russians have gone too far in subjecting the child and his peer group to conformity to a single set of values imposed by the adult society, perhaps we have reached the point of diminishing returns in allowing excessive autonomy and in failing to utilize the constructive potential of the peer group in developing social responsibility and consideration for others.”
—Urie Bronfenbrenner (b. 1917)