Santee may refer to:
Places:
- Santee, California
- Santee, Nebraska
- Santee, South Carolina
- Santee River in South Carolina
- Santee Education Complex, Los Angeles, California
- Lake Santee, Indiana, a reservoir and census-designated place
Plumbing:
- Santee, plumbing fitting: a portmanteau of "sanitation" and "tee," referring to a tee joint in a sanitation line
Ships:
- The USS Santee (1855)
- The USS Santee (CVE-29)
Other:
- Santee Sioux, a Sioux division
- Santee Indian Reservation in Nebraska
- Santee tribe, an Indian tribe officially recognized by South Carolina
- Santee (film), a 1973 western starring Glenn Ford