Sanguinetti is a family name that may refer to:
- Davide Sanguinetti (born 1972), Italian professional tennis player
- Gianfranco Sanguinetti, Italian writer and member of the Situationist International
- Guillermo Sanguinetti (born 1966), Uruguayan retired football defender
- Javier Sanguinetti (born 1971), Argentinian retired football defender
- Jorge Sanguinetti (born 1934), Uruguayan politician
- Julio María Sanguinetti (born 1936), Uruguayan president 1985-1990, 1995-2000
- Raúl Sanguinetti (1933–2000), Argentinian International Grandmaster of chess
- Robert Sanguinetti (born 1988), American ice hockey defenceman
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