Main Characters
- Amanda Tapping as Dr. Helen Magnus, an English medical and scientific researcher who has devoted her life to both hunting and protecting Abnormals—creatures with genetic abnormalities. She runs a "Sanctuary" in the fictional Old City, where the Abnormals may find refuge while she attempts to help them and to understand them further.
- Robin Dunne as Dr. Will Zimmerman, a forensic psychiatrist who is recruited by Dr. Magnus to help her treat Abnormals.
- Ryan Robbins as Henry Foss (webisodes, recurring season 1, main season 2-4), a technological wiz and lycanthrope.
- Christopher Heyerdahl as Bigfoot, a former Neanderthal-like patient of Dr. Magnus who would not leave after he recovered, so Dr. Magnus offered him a position at the Sanctuary as a butler, chauffeur, and body guard. Heyerdahl also plays the recurring character John Druitt.
- Agam Darshi as Kate Freelander (main season 2–3, recurring season 4), a con-artist with Cabal connection who has a vast knowledge of their tactics and movements. After she is hunted by the Cabal, she reluctantly switches sides to the Sanctuary, staying on as a member of the team.
- Emilie Ullerup as Ashley Magnus (webisodes, main season 1–2), the daughter of Dr. Magnus and John Druitt. Ashley is an expert monster hunter, and provides a counterbalance to Dr. Magnus's desire to protect creatures.
Read more about this topic: Sanctuary (TV Series)
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