Runx1

RUNX1

Identifiers Symbols RUNX1; AML1; AML1-EVI-1; AMLCR1; CBFA2; EVI-1; PEBP2aB External IDs OMIM: 151385 HomoloGene: 1331 ChEMBL: 1615385 GeneCards: RUNX1 Gene

Gene Ontology
Molecular function	• regulatory region DNA binding • DNA binding • sequence-specific DNA binding transcription factor activity • calcium ion binding • protein binding • ATP binding • transcription factor binding • protein homodimerization activity • protein heterodimerization activity • repressing transcription factor binding
Cellular component	• basement membrane • nucleus • nucleolus • intracellular membrane-bounded organelle
Biological process	• skeletal system development • in utero embryonic development • liver development • myeloid progenitor cell differentiation • transcription, DNA-dependent • central nervous system development • regulation of signal transduction • hemopoiesis • myeloid cell differentiation • negative regulation of granulocyte differentiation • positive regulation of granulocyte differentiation • hair follicle morphogenesis • embryonic hemopoiesis • positive regulation of angiogenesis • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • behavioral response to pain • peripheral nervous system neuron development • definitive hemopoiesis • regulation of hair follicle cell proliferation • hematopoietic stem cell proliferation • positive regulation of progesterone secretion
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 861 12394 Ensembl ENSG00000159216 ENSMUSG00000022952 UniProt Q01196 Q03347 RefSeq (mRNA) NM_001001890 NM_001111021 RefSeq (protein) NP_001001890 NP_001104491 Location (UCSC) Chr 21:
36.16 – 37.36 Mb Chr 16:
92.6 – 92.83 Mb PubMed search

Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene.