Roger Wilco may refer to:
- A voice procedure in two-way radio
- Roger Wilco (Space Quest), the main character in the Space Quest series of computer games
- Roger Wilco (Get Fuzzy), the brother of Rob Wilco in the comic strip Get Fuzzy
- Roger Wilco (software), a Voice over IP application
- "Roger Wilco", a song by Shawn Colvin from Whole New You