REV3L

REV3L

Identifiers Symbols REV3L; POLZ; REV3 External IDs OMIM: 602776 MGI: 1337131 HomoloGene: 48147 GeneCards: REV3L Gene EC number 2.7.7.7

Gene Ontology
Molecular function	• nucleotide binding • DNA binding • DNA-directed DNA polymerase activity • 3'-5' exonuclease activity • metal ion binding • 4 iron, 4 sulfur cluster binding
Cellular component	• nucleus • chromosome • zeta DNA polymerase complex
Biological process	• DNA-dependent DNA replication • nucleotide-excision repair, DNA gap filling • translesion synthesis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5980 19714 Ensembl ENSG00000009413 ENSMUSG00000019841 UniProt O60673 Q61493 RefSeq (mRNA) NM_002912 NM_011264 RefSeq (protein) NP_002903 NP_035394 Location (UCSC) Chr 6:
111.62 – 111.8 Mb Chr 10:
39.73 – 39.88 Mb PubMed search

Protein reversionless 3-like (REV3L) also known as DNA polymerase zeta catalytic subunit (POLZ) is an enzyme that in humans is encoded by the REV3L gene.

The Rev3 subunit interacts with Rev7 to form Pol ζ, a B family polymerase. Pol ζ lacks 3' to 5' exonuclease activity and is a moderate fidelity polymerase. It cannot add nucleotides across from DNA lesions, yet it can extend from primers with terminal mismatches. This makes Pol ζ very important in translesion synthesis (TLS), because it can act in concert with other TLS polymerases that can add across the lesion to complete the bypass of the lesion. Most polymerases have difficulty extending mismatches because they cannot bind properly to the mismatched DNA. So rather than the cell dying, it can survive albeit with a mutation that may or may not be deleterious, so it is believed that Pol ζ is a driving force of evolution.