The term resistance mutation is most commonly used to describe point mutations in virus genes that allow the virus to become resistant to treatment with a particular antiviral drug. The term is now being seen with more frequency in bacteriology and parasitology. The term "resistance mutation" first appeared in the management of HIV, which was the first virus in which genome sequencing is routinely used to look for drug resistance.
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“The free man is a warrior.—How is freedom measured among individuals, among peoples? According to the resistance that must be overcome, according to the trouble it takes to stay on top. The highest type of free man must be sought where the highest resistance is constantly overcome: five steps away from tyranny, close to the threshold of the danger of servitude.”
—Friedrich Nietzsche (1844–1900)