Cast
- Adam Sandler as Dr. Charlie Fineman
- Don Cheadle as Dr. Alan Johnson
- Jada Pinkett Smith as Janeane Johnson
- Liv Tyler as Dr. Angela Oakhurst
- Saffron Burrows as Donna Remar
- Donald Sutherland as Judge Raines
- Robert Klein as Jonathan Timpleman
- Melinda Dillon as Ginger Timpleman
- Mike Binder as Bryan Sugarman
- Jonathan Banks as Stelter
- John de Lancie as Nigel Pennington
- Rae Allen as Adell Modell
- Paula Newsome as Melanie
- Ted Raimi as Peter Saravino
- B. J. Novak as Fallon
- Joey King as Gina Fineman (uncredited)
Tom Cruise and Javier Bardem were initially signed on to play Adam Sandler's role and Don Cheadle's role, respectively. Jennifer Garner was initially signed on to play Liv Tyler's role. When Cruise dropped out, Bardem suggested Sandler after seeing him in Punch-Drunk Love. Although Sandler was initially hesitant about the project, he signed on after reading the script for a second time. Bardem later dropped from the project, so Cheadle was given the role.
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