Medical Uses
The combination of pyridoxine, more commonly referred to as vitamine B6, and doxylamine, an anti-histamine, is prescribed in Canada (as Diclectin) for the management of nausea and vomiting of pregnancy). No epidemiological studies have found any teratogenic effect. Doxylamine and pyridoxine are classified as a Risk Factor A drugs. This classification system is used in Drugs in Pregnancy and Lactation (8th edition), and utilizes the same definitions as the FDA pregnancy category drug classification.
A randomized, double-blind, placebo-controlled study demonstrated that the combination of 10 mg of pyridoxine and 10 mg of doxylamine in a delayed-release tablet is effective in reducing symptoms of nausea and vomiting of pregnancy.
Read more about this topic: Pyridoxine/doxylamine
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